abstract：:This study aimed to evaluate the extrapulmonary effects of exposure to cigarette smoke (CS) through the analysis of blood components and histopathological examinations of the trachea and diaphragm muscle (DM) in C57BL/6 mice. Thirty-six animals were exposed to six cigarettes per day for 5 days. The mice were divided i...

journal_title：Toxicology and industrial health

authors： Martins TL,Campos KKD,Araújo NPDS,Machado DF,Bezerra FS

更新日期：2017-09-01 00:00:00

abstract：:The present study investigates the toxic effects of acrylamide (ACR) administered to rats at two doses on (i) oxidative stress and disruption of pro-oxidant/antioxidant balance in hepatic cells and (ii) its correlation with metallothioneins (MTs) genes expression, DNA damage and histomorphological changes. Treated rat...

journal_title：Toxicology and industrial health

authors： Ghorbel I,Elwej A,Chaabene M,Boudawara O,Marrakchi R,Jamoussi K,Boudawara TS,Zeghal N

更新日期：2017-08-01 00:00:00

abstract：:Cobalt oxide (Co3O4) nanoparticles have applications in nanomedicine and nanotechnology; therefore, any possible adverse effects require thorough investigation. The present study investigated the effects of Co3O4 nanoparticles on four different cell lines: liver, HepG2 hepatocellular carcinoma cells; lung, A549 lung c...

journal_title：Toxicology and industrial health

authors： Abudayyak M,Gurkaynak TA,Özhan G

更新日期：2017-08-01 00:00:00

abstract：:Metalworking fluids (MWFs) are complex formulations designed for effective lubricating, cooling, and cleaning tools and parts during machining operations. Adverse health effects such as respiratory symptoms, dermatitis, and cancer have been reported in workers exposed to MWFs. Several constituents of MWFs have been im...

journal_title：Toxicology and industrial health

authors： Ryan KR,Cesta MF,Herbert R,Brix A,Cora M,Witt K,Kissling G,Morgan DL

更新日期：2017-05-01 00:00:00

abstract：:The aim of the present study was to assess and compare the individual adverse effects of bisphenol A (BPA) and octylphenol (OP) on the reproductive system of prepubertal male rats. Rats were exposed to BPA and OP at doses of 125 and 250 mg/kg/day, by gavage, for 90 days. At the end of the study, the testes, epididymis...

journal_title：Toxicology and industrial health

authors： Ahbab MA,Barlas N,Karabulut G

更新日期：2017-02-01 00:00:00

abstract：:Octamethylcyclotetrasiloxane (D4; CAS No. 556-67-2) is used as a monomer in the manufacture of polymeric materials, which are widely used in various industrial and/or medical applications, such as breast implants. D4 has a relatively low order of toxicity following acute administration via the oral, dermal, and inhala...

journal_title：Toxicology and industrial health

authors：

更新日期：2017-01-01 00:00:00

abstract：:Previous cross-sectional studies have shown that exposure to cleaning chemicals among health-care workers (HCWs) is associated with respiratory disorders and ventilatory function changes. This study aimed to further explore this association using a longitudinal approach. A prospective 2-year follow-up study was carrie...

journal_title：Toxicology and industrial health

authors： El-Helaly M,Balkhy HH,Waseem K,Khawaja S

更新日期：2016-12-01 00:00:00

abstract：:Zinc oxide nanoparticles (ZnONP) are manufactured on a large scale and can be found in a variety of consumer products, such as sunscreens, lotions, paints and food additives. Few studies have been carried out on its genotoxic potential and related mechanisms in whole organisms. In the present study, the in vivo genoto...

journal_title：Toxicology and industrial health

authors： Carmona ER,Inostroza-Blancheteau C,Rubio L,Marcos R

更新日期：2016-12-01 00:00:00

abstract：:The negative health effects caused by lead (Pb) exposure are widely recognized; however, the molecular mechanisms remain unknown. The aim of this study was to assess the effect of occupational Pb exposure on telomere length and to investigate the potential mechanisms leading to telomere shortening. A cohort of 334 mal...

journal_title：Toxicology and industrial health

authors： Pawlas N,Płachetka A,Kozłowska A,Mikołajczyk A,Kasperczyk A,Dobrakowski M,Kasperczyk S

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVES:In this study, biological exposure indicators were used to assess the exposure of workers to cadmium (Cd), lead (Pb), manganese (Mn), and nickel (Ni) in nonferrous metal smelters. METHODS:A total of 273 male participants (178 exposed and 95 nonexposed control group), working in nonferrous metal foundries lo...

journal_title：Toxicology and industrial health

authors： Dos Santos CR,da Silva CS,Nascimento ES

更新日期：2016-10-01 00:00:00

abstract：:Microcystins (MCs) are the most potent toxins that can be produced by cyanobacteria in drinking water supplies. This study investigated the abundance of toxin-producing algae in 11 drinking water treatment plants (DWTPs). A total of 26 different algal taxa were identified in treated water, from which 12% were blue gre...

journal_title：Toxicology and industrial health

authors： Ibrahim WM,Salim EH,Azab YA,Ismail AH

更新日期：2016-10-01 00:00:00

abstract：:T-2 toxin is one of the mycotoxins, a group of type A trichothecenes produced by several fungal genera including Fusarium species, which may lead to the decrease of testosterone secretion in primary Leydig cells derived from mouse testis. The previous study demonstrated T-2 toxin decrease the testosterone biosynthesis...

journal_title：Toxicology and industrial health

authors： Yang JY,Zhang YF,Li YX,Guan GP,Kong XF,Liang AM,Ma KW,Da Li G,Bai XF

更新日期：2016-10-01 00:00:00

abstract：:This study focuses on investigating the possible protective effect of sodium selenite (Na2SeO3) and/or vitamin E against mercuric chloride (HgCl2)-induced hepatotoxicity in rat. Male rats were given HgCl2 (1 mg/kg body weight (bw)) and HgCl2 plus Na2SeO3 (0.25 mg/kg bw) and/or vitamin E (100 mg/kg bw) daily via gavage...

journal_title：Toxicology and industrial health

authors： Uzunhisarcikli M,Aslanturk A,Kalender S,Apaydin FG,Bas H

更新日期：2016-09-01 00:00:00

abstract：:1,2-Dichloropropane (1,2-DCP), a solvent, which is the main component of the cleaner used in the offset printing companies in Japan, is suspected to be the causative agent of bile duct cancer, which has been recently reported at high incidence in those offset printing workplaces. While there are some reports about the...

journal_title：Toxicology and industrial health

authors： Yanagiba Y,Suzuki T,Suda M,Hojo R,Gonzalez FJ,Nakajima T,Wang RS

更新日期：2016-09-01 00:00:00

abstract：:Phthalates are abundantly produced plasticizers, and dibutyl phthalate (DBP) is the most widely used derivative in various consumer products and medical devices. This study was conducted to further explore the potential testicular toxicity of DBP in adult rats and to elucidate the underlying mechanisms. Adult male alb...

journal_title：Toxicology and industrial health

authors： Aly HA,Hassan MH,El-Beshbishy HA,Alahdal AM,Osman AM

更新日期：2016-08-01 00:00:00

abstract：:The aim of this study was to investigate the effect of oral cadmium (Cd) intoxication on the antioxidant response and its relationship with essential bioelements like copper (Cu) and zinc (Zn). The experimental group was chronically exposed to Cd daily for 8 weeks via consumption of water containing 15 ppm cadmium chl...

journal_title：Toxicology and industrial health

authors： Erdem O,Yazihan N,Kocak MK,Sayal A,Akcil E

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:Polycyclic aromatic hydrocarbons (PAHs) are potent environmental pollutants. Benzo[α]pyrene (B[α]P) is the major compound of PAHs that acts by activating aryl hydrocarbon receptor (AhR) in cells. B[α]P is a known carcinogen and an immunotoxicant; however, its role with regard to nuclear factor of activated T ...

journal_title：Toxicology and industrial health

authors： Parsa M,Ostad SN,Moogahi SM,Bayat M,Ghahremani MH

更新日期：2016-07-01 00:00:00

abstract：:Pesticides are omnipresent in environment, water, fruits, and vegetables and are considered as risk factors for human health. Consumers are mainly exposed to pesticides through diet, and the main question to be answered concerns the impact of such exposure on health. In this study, we developed a mouse model to mimic ...

journal_title：Toxicology and industrial health

authors： Mansour SA,Gamet-Payrastre L

更新日期：2016-07-01 00:00:00

abstract：:This study was realized to investigate the possible beneficial effect of thymoquinone (TQ), the major active component of volatile oil of Nigella sativa seeds, against lead (Pb)-induced inhibition of rat testicular functions. Adult rats were randomized into four groups: a control group receiving no treatment; a Pb gro...

journal_title：Toxicology and industrial health

authors： Mabrouk A,Ben Cheikh H

更新日期：2016-06-01 00:00:00

abstract：:Cucumbers grown in two different greenhouses were exposed to mancozeb and carbaryl at different times. The effects of 10-day preharvest period, water and detergent washing, peeling, predetermined storage period at 4°C (refrigeration), and fermentation on the reduction of residue levels in the plant tissues were invest...

journal_title：Toxicology and industrial health

authors： Saeedi Saravi SS,Shokrzadeh M

更新日期：2016-06-01 00:00:00

abstract：:Some studies have shown that exposure to electromagnetic field (EMF) may result in structural damage to neurons. In this study, we have elucidated the alteration in the hippocampal function of offspring Wistar rats (n = 8 rats in each group) that were chronically exposed to mobile phones during their gestational perio...

journal_title：Toxicology and industrial health

authors： Razavinasab M,Moazzami K,Shabani M

更新日期：2016-06-01 00:00:00

abstract：:A more complicated pathology was observed in female pigs infected with Mycoplasma hyopneumoniae, when the same were exposed to 20 ppm dietary levels of fumonisin B1 (FB1) starting 14 days before infection for a period of 42 days as was assessed by gross pathology and pathomorphological examinations or computed tomogra...

journal_title：Toxicology and industrial health

authors： Pósa R,Stoev S,Kovács M,Donkó T,Repa I,Magyar T

更新日期：2016-06-01 00:00:00

abstract：:Carvacrol (CVC), a major constituent of genera Origanum and Thymus, is such a substance that has attracted attention because of its wide variety of beneficial biological activities such as antibacterial, antifungal, and anticancer effects. However, there are limited data on the cytogenetic and antioxidant effects of C...

journal_title：Toxicology and industrial health

authors： Türkez H,Aydın E

更新日期：2016-04-01 00:00:00

abstract：:This study on the effect of genetically modified (GM) and non-GM canola on soybean was carried out for physiological and biochemical biosafety assessment of GM canola. Methanolic extracts of GM and non-GM canola were assessed on seed germination and growth of soybean (Glycine max L.) under sterilized conditions. The e...

journal_title：Toxicology and industrial health

authors： Syed K,Shinwari ZK

更新日期：2016-03-01 00:00:00

abstract：:In the present work, 6 honeydew samples of known geographical and botanical origins and 11 honeybee samples were analyzed to detect possible contamination by the thermoelectric power plants in Mugla, Turkey. The contents of trace elements were determined by atomic absorption spectrometry after application of microwave...

journal_title：Toxicology and industrial health

authors： Silici S,Uluozlu OD,Tuzen M,Soylak M

更新日期：2016-03-01 00:00:00

abstract：:In the recent years, there has been a growing interest in monitoring heavy metal contamination of spices/herbs. Spices and herbs are sources of many bioactive compounds that can improve the tastes of food as well as influence digestion and metabolism processes. In the present study, the levels of some essential and to...

journal_title：Toxicology and industrial health

authors： Seddigi ZS,Kandhro GA,Shah F,Danish E,Soylak M

更新日期：2016-02-01 00:00:00

abstract：:The purpose of this study is to follow-up the distribution, lethality percentile doses (LDs) and bioaccumulation of aluminium oxide nanoparticles (Al2O3-NPs, average diameter 9.83 ± 1.61 nm) in some tissues of male albino rats, and to evaluate its genotoxicity to the brain tissues, during acute and sublethal experimen...

journal_title：Toxicology and industrial health

authors： Morsy GM,El-Ala KS,Ali AA

更新日期：2016-02-01 00:00:00

abstract：:Paraquat has been shown to be a highly toxic compound for humans and animals, and many cases of acute poisoning and death have been reported over the past few decades. The present study was undertaken to evaluate comprehensively herbicides (Paraquat) and some plant extracts to biochemical aspects of Lymnaea natalensis...

journal_title：Toxicology and industrial health

authors： Bakry FA,Eleiwa ME,Taha SA,Ismil SM

更新日期：2016-01-01 00:00:00

abstract：:Elaeagnus angustifolia was analyzed for determination of metals, phytoconstituents, bactericidal, fungicidal and insecticidal effects and to explore its chemical and biological potential. The root, branches, leaves, stem bark and root bark parts of E. angustifolia were found to contain iron, lead, copper, cadmium, zin...

journal_title：Toxicology and industrial health

authors： Khan SU,Khan AU,Shah AU,Shah SM,Hussain S,Ayaz M,Ayaz S

更新日期：2016-01-01 00:00:00

abstract：:Acetaminophen (APAP) is widely used in the treatment of pain. Toxic doses of APAP cause acute liver failure, but therapeutic doses are believed to be safe. The purpose of this study is to investigate the effects of administration of subtoxic doses of APAP on liver and blood levels of insulin-like growth factor-1 (IGF-...

journal_title：Toxicology and industrial health

authors： Ozdemir D,Aksu I,Baykara B,Ates M,Sisman AR,Kiray M,Buyuk A,Uysal N

更新日期：2016-01-01 00:00:00

abstract：:Natural products possessing antioxidant properties play a very crucial role in ameliorating deleterious effects of reactive oxygen species. This study investigated the chemoprotective properties of methanolic extract of Vernonia amygdalina (MEVA) in an experimental model of hepatic oxidative damage induced by 2-acetyl...

journal_title：Toxicology and industrial health

authors： Adesanoye OA,Adekunle AE,Adewale OB,Mbagwu AE,Delima AA,Adefegha SA,Molehin OR,Farombi EO

更新日期：2016-01-01 00:00:00

abstract：:Aflatoxin B1 (AFB1) is a toxic compound commonly found as a contaminant in human food. It is carcinogenic due its potential in inducing the oxidative stress and distortion of the most antioxidant enzymes. Since black tea possesses strong antioxidant activity, it protects cells and tissues against oxidative stress. Cur...

journal_title：Toxicology and industrial health

authors： Alm-Eldeen AA,Mona MH,Shati AA,El-Mekkawy HI

更新日期：2015-12-01 00:00:00

abstract：:Copper (Cu) in trace amounts is essential for biological organisms. However, dysregulation of the redox-active metal has been implicated in different neurological disorders such as Wilson's, Menkes', Alzheimer's, and Parkinson's diseases. Since many households use Cu tubing in the plumbing system, and corrosion causes...

journal_title：Toxicology and industrial health

authors： Lung S,Li H,Bondy SC,Campbell A

更新日期：2015-12-01 00:00:00

abstract：:Organophosphate (OP) compounds are the most commonly used pesticide groups and they are commercially used in the market for local and industrial purposes. Paraoxonase 1 (PON1) enzyme plays an important role in biotransformation of OP compounds, which shows toxic effects via inhibiting the acetylcholinesterase (AChE). ...

journal_title：Toxicology and industrial health

authors： Sunay SZ,Kayaaltı Z,Bayrak T,Söylemezoğlu T

更新日期：2015-12-01 00:00:00

abstract：:Ferric nitrilotriacetate (Fe-NTA) is a known renal carcinogen and has been shown to adversely induce oxidative stress and tissue toxicity after both acute and chronic exposure. Present studies were designed to study the hepatoprotective and antioxidant potential of butylated hydroxyanisole (BHA), a phenolic antioxidan...

journal_title：Toxicology and industrial health

authors： Ansar S,Iqbal M

更新日期：2015-11-01 00:00:00

abstract：:In allelopathy, one plant suppresses the growth and development of other plant/plants by negatively affecting a variety of physiological and biochemical reactions. We checked the effects of methanolic extracts (allelochemical extracts) of Phytolacca latbenia (Moq.) H. Walter on antioxidant enzyme activities such as pe...

journal_title：Toxicology and industrial health

authors： Ullah N,Haq IU,Safdar N,Mirza B

更新日期：2015-10-01 00:00:00

abstract：:Cisplatin (CP) is a widely used anticancer drug; however, it has several side effects such as nephrotoxicity. Ginger, the rhizome of Zingiber officinale, consumed since ancient times has numerous health benefits. The objective of this work was to evaluate the protective effect of ginger extract (GE) against CP-induced...

journal_title：Toxicology and industrial health

authors： Ali DA,Abdeen AM,Ismail MF,Mostafa MA

更新日期：2015-10-01 00:00:00

abstract：:Penile fracture (PF) is known as a traumatic rupture of the tunica albuginea of corpus cavernosum. In this study, we aimed to investigate the healing influence of topical extra virgin olive oil (EVOO) on PF through evaluating levels of some oxidative stress biomarkers for the first time. Histopathological evaluation w...

journal_title：Toxicology and industrial health

authors： Gunes M,Ozkol H,Pirincci N,Gecit I,Bilici S,Yildirim S

更新日期：2015-08-01 00:00:00

abstract：:The concentrations of heavy metals (cadmium (Cd), copper (Cu), nickel (Ni), lead (Pb) and zinc (Zn)) were measured in hepatopancreas and muscle of a commercial shrimp (Metapenaeus affinis), in the muscle, liver and gills of two fish species (Thryssa vitrirostris and Johnius belangerii) and in the sediment samples take...

journal_title：Toxicology and industrial health

authors： Monikh FA,Maryamabadi A,Savari A,Ghanemi K

更新日期：2015-06-01 00:00:00

abstract：:The aim of the present study was to determine the effects of extremely low-frequency magnetic field (ELF-MF) on accumulation of manganese (Mn) in the kidney, liver and brain of rats. A total of 40 rats were randomly divided into eight groups. Four control groups received 0, 3.75, 15 and 60 mg Mn per kg body weight ora...

journal_title：Toxicology and industrial health

authors： Çelik MS,Güven K,Akpolat V,Akdağ MZ,Nazıroğlu M,Gül-Güven R,Çelik MY,Erdoğan S

更新日期：2015-06-01 00:00:00